Power-law Models for Infectious Disease Spread1 by Sebastian Meyer

Short-time human travel behaviour can be well described by a power law with respect to distance. We incorporate this information in space-time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a space-time point process model for individual point-referenced data, and a multivariate time series model for aggregated count data. In both frameworks, the power-law spread is embedded into the epidemic component and its decay parameter is estimated simultaneously with all other unknown parameters using (penalised) likelihood inference. The performance of the new approach is investigated by a re-analysis of individual cases of invasive meningococcal disease in Germany (2002-2008), and count data on influenza in 140 administrative districts of Southern Germany (2001-2008). In both applications, the power-law formulations substantially improve model fit and predictions. Implementation in the R package surveillance allows to apply the approach in other settings. DOI: https://doi.org/10.1214/14-AOAS743 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-89321 Originally published at: Meyer, Sebastian; Held, Leonhard (2014). Power-law models for infectious disease spread. Annals of Applied Statistics, 8(3):1612-1639. DOI: https://doi.org/10.1214/14-AOAS743 The Annals of Applied Statistics 2014, Vol. 8, No. 3, 1612–1639 DOI: 10.1214/14-AOAS743 © Institute of Mathematical Statistics, 2014 POWER-LAW MODELS FOR INFECTIOUS DISEASE SPREAD1 BY SEBASTIAN MEYER AND LEONHARD HELD University of Zurich Short-time human travel behaviour can be described by a power law with respect to distance. We incorporate this information in space–time models for infectious disease surveillance data to better capture the dynamics of disease spread. Two previously established model classes are extended, which both decompose disease risk additively into endemic and epidemic components: a spatio-temporal point process model for individual-level data and a multivariate time-series model for aggregated count data. In both frameworks, a power-law decay of spatial interaction is embedded into the epidemic component and estimated jointly with all other unknown parameters using (penalised) likelihood inference. Whereas the power law can be based on Euclidean distance in the point process model, a novel formulation is proposed for count data where the power law depends on the order of the neighbourhood of discrete spatial units. The performance of the new approach is investigated by a reanalysis of individual cases of invasive meningococcal disease in Germany (2002–2008) and count data on influenza in 140 administrative districts of Southern Germany (2001–2008). In both applications, the power law substantially improves model fit and predictions, and is reasonably close to alternative qualitative formulations, where distance and order of neighbourhood, respectively, are treated as a factor. Implementation in the R package surveillance allows the approach to be applied in other settings.